Tissue-specific cancer paradox and mutation rates
نویسنده
چکیده
There are certain genes that have ubiquitous expression patterns in an individual’s cells; yet, a paradox exists whereby mutations (germline or somatic) in such genes are only strongly associated with cancers of specific tissues. As these genes are ubiquitously expressed in the body’s cells and thereby have functions in -potentiallyall tissue types, then surely their resulting defects would manifest as cancers in all tissues? (Blighe, 2014).
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